DermRx Decision Support
Dermatology

Evidence-based
drug selection
for dermatology

Select a tool below to generate personalized recommendations with contraindication alerts based on patient profile and comorbidities.

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Injection-based therapies
Biologics
Subcutaneous and IV biologic agents for psoriasis, atopic dermatitis, HS, prurigo nodularis, CSU, and bullous pemphigoid.
IL-17 inhibitors IL-23 inhibitors TNF-α inhibitors IL-4Rα inhibitors IL-13 inhibitors IL-31Rα Anti-IgE
Open biologics form
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Oral & topical therapies
JAK & TYK2
Inhibitors
Oral and topical small molecule inhibitors for psoriasis, atopic dermatitis, alopecia areata, PsA, HS, and vitiligo. Includes black box warning screening.
Upadacitinib Abrocitinib Baricitinib Deucravacitinib Ruxolitinib cream Tofacitinib
Open JAK/TYK2 form

Not a substitute for clinical judgment or institutional prescribing guidelines. For educational and clinical decision support purposes only.

Pipeline & ongoing clinical trials Updated April 2026
Psoriasis
FDA Approved
Icotrokinra (Icotyde) — J&J
First oral IL-23R antagonist (cyclic peptide). Approved March 18, 2026 for plaque psoriasis ≥12y and ≥40kg. 200mg once daily oral. Superior to deucravacitinib in head-to-head Phase 3 (PASI 90: 55% vs 30%). No BBW. ICONIC-ASCEND (vs. ustekinumab) ongoing.
NDA Filing
Zasocitinib (TAK-279) — Takeda
Next-gen TYK2 inhibitor. Phase 3 (LATITUDE-PsO-3001/3002) positive. NDA filing planned 2026. Phase 3 for PsA ongoing.
NDA Filing
Envudeucitinib (ESK-001) — Alumis
Next-gen TYK2 inhibitor. Phase 3 (ONWARD1/2) positive — PASI 75 ~74%. NDA filing H2 2026. ONWARD3 extension ongoing.
Atopic Dermatitis
BLA Filing
Amlitelimab — Sanofi
Anti-OX40L biologic. Phase 3 (COAST 1/2, SHORE) positive. Global regulatory submissions planned H2 2026. Q4W or Q12W dosing.
Phase 3
Soficitinib (ICP-332) — Innocare
Oral TYK2 inhibitor for AD. Phase 2 positive (JAMA Derm 2026). Phase 3 (579 patients) underway.
Discontinued
Rocatinlimab — Kyowa Kirin / Amgen
Anti-OX40 biologic. Phase 3 met endpoints but discontinued March 2026 due to emerging safety concerns.
Hidradenitis Suppurativa
NDA Filing
Povorcitinib — Incyte
Oral JAK1 inhibitor. Phase 3 (STOP-HS1/2) positive — HiSCR50 ~60–71%. NDA filing late 2025/early 2026. Also Phase 3 for vitiligo and PN.
BLA Filing
Sonelokimab — MoonLake
IL-17A/F nanobody. Phase 3 (VELA-1/2) — VELA-1 met endpoint; VELA-2 narrowly missed. BLA filing planned H2 2026. Week 40 data: HiSCR75 62%.
Alopecia Areata · Vitiligo · Other
Phase 3
Upadacitinib (vitiligo) — AbbVie
Phase 3 (Viti-Up) met co-primary endpoints. FDA/EMA submissions filed. First systemic therapy for vitiligo.
Phase 3
Ritlecitinib (vitiligo) — Pfizer
JAK3/TEC inhibitor. Phase 3 for vitiligo ongoing (est. completion 2026). Already approved for alopecia areata (Litfulo).
Phase 3
Brepocitinib — Priovant
Oral TYK2/JAK1 inhibitor. Phase 3 (VALOR) positive for dermatomyositis — first targeted therapy for this condition. Priority Review expected.
ⓘ  Trials listed reflect late-stage (Phase 2b–3) programs with data presented at AAD 2026, EADV 2025, or published as of April 2026. Phase status reflects most recent available data. NDA/BLA = New Drug Application / Biologics License Application filing with FDA. This section is updated periodically — visit ClinicalTrials.gov for real-time status.
Evidence base & sources
AAD Clinical Guidelines
American Academy of Dermatology practice guidelines for psoriasis, atopic dermatitis, hidradenitis suppurativa, and alopecia areata — the primary evidence-based standard for US dermatology practice.
FDA Prescribing Information
Official FDA-approved labels for every biologic, JAK inhibitor, and TYK2 inhibitor in the tool — authoritative source for approved indications, dosing schedules, contraindications, and black box warnings.
Landmark Clinical Trials
Phase 3 registration trials published in NEJM, Lancet, and JAAD including SOLO 1&2, ERASURE/FIXTURE, BE SURE, VOYAGE, UltIMMa, BRAVE-AA, TRuE-V, PIONEER, LIBERTY-BP, and others.
DermSquared Biologics Tool v9
Brownstone & Lebwohl (October 2025) — quick reference chart for approved biologic dosing across psoriasis, HS, AD, PN, CSU, and BP. Used as a cross-reference for dosing accuracy.
AAAAI / EAACI Guidelines
International urticaria guidelines used for chronic spontaneous urticaria biologic selection, including omalizumab and dupilumab positioning.
UpToDate
Evidence-based clinical decision support used to cross-reference treatment algorithms for psoriasis, atopic dermatitis, and other conditions covered in this tool.
Content is reviewed against current literature and updated periodically. DermRx is intended for clinical decision support and educational purposes only — not a substitute for clinical judgment or institutional prescribing guidelines. Clinicians should consult primary sources and current package inserts before prescribing.
Created by Aleena Boby, MD candidate — University of South Florida